|
1 / 1
|
DeCS
|
|
 |
|
Descriptor English:
|
|
Oncogene Proteins v-erbA
|
|
Descriptor Spanish:
|
|
Proteínas Oncogénicas v-erbA
|
|
Descriptor Portuguese:
|
|
Proteínas Oncogênicas v-erbA
|
|
Synonyms English:
|
|
erbA Oncogene Proteins
v-erbA Proteins
|
|
Tree Number:
|
|
D12.776.624.664.520.750.882
D12.776.964.700.750.882
D12.776.964.775.750.882
|
|
Definition English:
|
|
Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation. |
|
Indexing Annotation English:
|
|
IM; coord with specific virus (IM); /drug eff /ultrastruct permitted; DF: note short X ref
|
|
History Note English:
|
|
95; was ONCOGENE PROTEIN ERBA (NM) 1987-94
|
|
Allowable Qualifiers English:
|
|
|
|
Record Number:
|
|
32106
|
|
Unique Identifier:
|
|
D018774
|
Occurrence in VHL:
|
|
|
Similar:
|
|
DeCS CID-10 SciELO LILACS LIS
|